The Binding of Isaac: Rebirth – The Ultimate Guide

The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth is a favorite among fans of roguelike dungeon crawlers. It mixes dark humor with religious themes. This guide we have for you is packed with information. It covers the different characters, items, enemies, and bosses you’ll meet. You can learn advanced tips if you’re already experienced. If you’re just starting, this guide gives a solid introduction too.

Key Takeaways:

  • The game features a vast array of items, trinkets, and collectibles that significantly impact gameplay.
  • There are various characters to unlock, each with unique playstyles and abilities.
  • Enemies and bosses pose a challenge with their distinct attack patterns and behaviors.
  • Progression in the game unlocks new floors, bosses, and challenges, providing endless replayability.
  • Utilize resources such as guide apps and websites to enhance your understanding and optimize your gameplay.

Introduction to The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth is a top-down shooter known for its intense action and deep story. Players follow Isaac, a young boy, through a scary world. You face challenges, find cool items, and fight big bosses. This game offers hours of fun for those who love adventure and strategy.

This game is set in a dark world full of religious references. It’s unique because each game is different. Levels, enemies, and items change every time you play. This keeps the game exciting and brings back players to discover more.

What makes this game stand out is its blend of dark humor and deep themes. Players can mix and match items to find powerful combinations. There are also many secrets to uncover. This all adds up to a rich and rewarding gaming experience.

The Binding of Isaac: Rebirth is a game loved by many. Whether you enjoy rogue-likes or want a new challenge, it’s worth a try. With its captivating story and gameplay, it offers endless fun and surprises for players all around the world.

Controls and UI in The Binding of Isaac: Rebirth

Learning the controls and UI in The Binding of Isaac: Rebirth is key to beat the game’s tough enemies. Whether you’re using a keyboard, mouse, or controller, knowing how to do actions and use various tools makes the game fun.


In The Binding of Isaac: Rebirth, moving Isaac and fighting is easy. On a keyboard, use WASD to move and Arrow keys to attack. With a controller, move with the left stick and attack with the right.

Players can pick what control method they like. Try different ways to find what feels best for you.


The UI is key for info and decisions in The Binding of Isaac: Rebirth. It shows your:

  • Health: Your health is shown with heart types. But, it’s hidden by the Curse of the Unknown.
  • Coins, Bombs, and Keys: Know how many coins, bombs, and keys you have. This helps with planning.
  • Usable Items: See your active item to use it easily.
  • Floor Details and Maps: Map and room layouts are shown. Some things, like Curse of the Lost, can hide parts of the map temporarily.

Understanding the UI helps in making smart choices. It lets you see what items and enemies are coming up. This is important for winning.

Getting good with the controls and UI in The Binding of Isaac: Rebirth makes the game more enjoyable. Spend time learning them. This will help you survive the game’s challenges.


Goal of The Binding of Isaac: Rebirth

The goal of The Binding of Isaac: Rebirth is to go on an exciting journey. You move through dark dungeons and gather items. You must also defeat strong bosses. Your final task is to beat Mom, the last boss, in an epic battle.

As you move forward, you face dangers in levels that change every time you play. The game’s permadeath feature means you start fresh each time, making the challenge new and unpredictable.

Collecting items is key. These items boost your character’s skills and offer new powers. They might make you stronger, faster, or give you cool abilities or looks.

But, the journey to Mom is tough. You’ll meet many powerful enemies and bosses on the way. Each boss fight is different, challenging you to think fast and use your skills well.

Defeating Mom unlocks more floors and bosses, adding to the challenge. The game has lots to offer, especially with its expansions. These updates bring more to the game, including new stories, characters, and secrets.

Unlocking Completion Marks and Character Progression

Your progress in The Binding of Isaac: Rebirth is marked by completion marks. Finish special challenges to earn these marks. They show up as notes on your character’s page as you win.

Both Normal and Hard modes let you earn these marks. When you win one in Hard mode, you also get it in Normal mode. Some tough bosses offer special rewards, like Godhead, but only if you meet their hard requirements.

The number of marks has grown over time. There were 6 to start, then more as the game expanded. With bonuses in different modes, you can now claim up to 24 marks in Repentance.

There are also secret characters that offer fun twists. Tainted characters, for example, need to fulfill special goals. This adds to the game’s depth and gives players new challenges.

To get more marks in one go, use the right items and tactics. Items like Forget Me Now and Clicker help, letting you restart or change your character. Duplicating items also speeds up the mark-gathering process.

Getting all marks for some bosses might take several tries with different characters. However, playing in multiplayer mode can help by sharing progress among players. This adds a cooperative twist to the game.

Floor of ProgressionBoss of the FloorCompletion Mark
CavesGurdy Jr.
WombMom’s Heart/It Lives

The Binding of Isaac: Rebirth is a big, tough game. It’s full of surprises and challenges. Explore its dark, imaginative world and unlock all its secrets for endless hours of fun.

Characters in The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth features many unique characters. Each comes with special skills and tactics. It’s important to know how to use their strengths to win.

The game boasts a total of 14 characters. You start with 11 in the base game. The Afterbirth DLC brings in 2 more. And the Afterbirth+ DLC includes 1 additional character.

Every character requires unique conditions to unlock them. They also start with different items. This affects how you will play the game.

As you play, you will earn Post-it notes for your victories. They show your progress against tough bosses. This adds a sense of accomplishment to your journey.

To unlock more items and characters, you must beat specific bosses. Like Mom’s Heart, The Lamb, Mega Satan, or Hush. Doing this helps you grow in the game.

In Repentance, you’ll meet ‘tainted’ versions of all characters. This innovation boosts complexity and fun in the game.

The creator of the game has said each character symbolizes something about Isaac. This makes the story even more interesting.

Certain notable playable characters include:

CharacterStarting StatsUnlock Requirements
Magdalene4 full red heartsAvailable from the start
Cain2 full red heartsCollect 55 coins
Judas1 full red heartDefeat Satan
???3 full soul heartsDefeat Mom’s Heart 10 times
Eve2 full red hearts (damage increases to 3.5 with 1 full heart remaining)Avoid picking up hearts for two consecutive floors
Samson3 full red heartsDo not take damage for two consecutive floors
Azazel3 full black heartsMake three deals with the Devil in one run
Lazarus3 full red heartsHave 4 soul or black hearts simultaneously
EdenRandom statsComplete The Womb
The LostNo healthDie in a Sacrifice Room while holding the Missing Poster item
Lilith1 full red heart and 2 full black heartsBeat Greed Mode with Azazel
Keeper2 coin heartsSignificant progress in Greed Mode

With so many characters available, The Binding of Isaac: Rebirth offers a new experience each time. Trying different characters is the key to discovering new strategies.

Items and Item Collection in The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth is packed with an array of items for players to find and use. These items change the game, offering boosts, new powers, and cool effects. Getting and using these items well is vital for winning.

In The Binding of Isaac: Rebirth, you must explore to find items>. They’re hidden in rooms, secret spots, and guarded by bosses. Each item you discover makes the game more interesting and boosts your chances of winning.

To find the best items, players need to be thorough in their exploration. Visit every room, use bombs wisely to find secrets, and collect keys for treasure. Doing this can get you items that make you stronger, give you special powers or work well together.

Mixing and matching items is a big deal in The Binding of Isaac: Rebirth. Some items combine well together, making each other more powerful in certain situations. Players must experiment and plan their use of items to make their character tough and hard to beat.

Here are some cool items you might find in the game:

Mom’s KnifeReplaces tears with a powerful knife projectile
BrimstoneFires a powerful continuous laser beam
TechnologyTransforms tears into laser beams that pierce enemies
PolyphemusSignificantly increases damage and size of tears

These are just a sample of the many cool and useful items in The Binding of Isaac: Rebirth. Learning how to collect and use items effectively improves your game. It makes surviving and winning easier.

Enemies and Bosses in The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth brings lots of enemies and tough bosses. Each one has its own way of attacking. You’ll need to change up your game plan to win.


As you journey, you’ll meet many different foes. They all have unique skills and traits. Here are a couple you might find:

  • Mulligans: They spawn Red or Black Flies when defeated, attacking in groups.
  • Gushers: They launch shots randomly, keeping you on your toes.
  • Gapers: Upon their defeat, they might turn into Pacers or Gushers, throwing a curveball your way.
  • Demonic Gapers: These are faster than regular Gapers and disappear at times. They’re hard to predict.
  • Maws: They fire red tears and do damage on contact. You need to be quick to avoid them.
  • Psychic Maws: These send homing tears after you. They’re tough since they’re protected by an Eternal Fly.

Enemies and Bosses


Boss fights are where your skills are really put to the test. Beat them to get items that help you. Here’s a look at some of the big bosses:

  • Super Gapers: When they go down, tears fly every which way. Watch out, they might summon more foes too.
  • Mega Gapers: They jump, firing tears all around. Their jump leaves a bloody trail, making the battlefield more dangerous.
  • Psychic Horfs: They have homing tears just like Psychic Maws. Precision and quick moves are key against them.
  • Hush Flies: They fly in complex patterns around the powerful Hush boss, making the fight more intricate.
Enemy/Boss TypeSpecial Abilities
MulligansSpawn Red or Black Flies when killed
GushersSometimes shoot out a red tear in random directions
GapersSometimes turn into Pacers or Gushers upon death
Demonic GapersFaster than regular Gapers and fade in and out of visibility
MawsShoot red tears when close to the player and deal contact damage

Winning against these foes and bosses means you get helpful items. It helps you move forward in The Binding of Isaac: Rebirth.

Unlockables and Character Progression in The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth has an interesting progression system. It lets players unlock new items, characters, and challenges by reaching certain goals. Character progression is key in changing the gameplay and finding new content.

Opening up new areas and facing new bosses is important. To get to the Womb, a player needs to beat Mom. After that, a way to the Womb will open in future runs. There’s also an item that can create a special entrance.

Players can reach Sheol and Cathedral by defeating Mom’s Heart multiple times. After these wins, they’ll find new paths open up. This adds more exploration and excitement to the game.

Special items are needed to reach The Dark Room and The Chest. For The Dark Room, players need The Negative to enter Satan’s chest. To open Isaac’s Chest in The Chest, The Polaroid is required. Defeating Satan and Isaac five times each will unlock these items.

The Dark Room also has an alternative entrance, through the Sacrifice Room. Collecting both Key Pieces will open the way to Mega Satan, a tough opponent to beat.

Unlocking certain areas and floors needs players to meet specific criteria. Extra floors can be unlocked too. This offers new challenges and surprises.

There are ways to skip some levels and go straight to others. This can help players try out new strategies and enjoy the game in different ways.

Character unlocks are a big part of the game. There are 34 different characters, each with their own stats. These stats shape how a player’s character performs.

Each character requires different tasks to unlock. They come with their own stories related to Isaac. This deepens the game’s meaning.

Unlockable Characters in The Binding of Isaac: Rebirth

Base Game CharactersDLC CharactersTainted Characters (Introduced in Repentance)
IsaacAzazelTainted Isaac
MaggieEdenTainted Maggie
JudasLilithTainted Judas
CainKeeperTainted Cain
EveLostTainted Eve
SamsonApollyonTainted Samson
AzazelForgottenTainted Azazel
LazarusJacobTainted Lazarus
EdenEsauTainted Eden
Blue BabyBethanyTainted Blue Baby

23 more characters were added with the DLCs, offering new playstyles. Repentance added tainted versions of all 17 characters, changing how they play.

To fully enjoy The Binding of Isaac: Rebirth, it’s important to understand how to unlock characters and more. This knowledge helps players tailor their experience and discover all the game has to offer.

DLCs and Additions to The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth is a popular rogue-like twin-stick shooter. It expanded its gameplay with several DLCs. Afterbirth, Afterbirth+, and Repentance bring more content, challenges, and modes for players to enjoy.

Afterbirth (2015)

The Afterbirth DLC was launched in 2015 after The Binding of Isaac: Rebirth’s success. It added many new things like items, enemies, and bosses. With a $10.99 price, it increased the game’s replay value.

Afterbirth+ (2017)

Afterbirth+ came out in 2017 to build on Afterbirth’s success. It introduced more items, enemies, and bosses. For $9.99, players could explore Isaac’s world even more.

Repentance (2021)

In 2021, Repentance became the most extensive expansion. It brought new co-op play, characters, and bosses. Priced at $14.99, it refreshes the game for players.

Reviewers and players praise the DLCs for enriching the base game. They’ve added a lot to The Binding of Isaac: Rebirth’s appeal and difficulty.

On platforms like Steam, players can buy the game and DLCs separately. All DLCs cost a bit over $60 on Steam for the full experience.

The Nintendo Switch version has most DLCs at a digital $40 price. But for $60, players can get a physical version with all content.

Existing owners of Afterbirth+ on Switch can get Repentance separately. This expands their gameplay options.

Players have spent hundreds of hours in the game across PC and Switch. This shows the game’s lasting appeal and value.

The DLCs deepen the world of Isaac, making them a great choice for fans. They offer more challenges and content for an immersive experience.

Essential Tools and Resources for The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth is challenging and fun. For a better game experience, you have many tools at your disposal. You can find modding support, guides, and editing tools. These can help you enjoy the game more and find new content.

Official Tools for Mod Creation

Afterbirth+ is the ideal game version for modding. It comes with special tools for making mods. With the Animation Editor, Item Pool Editor, and more, you can create unique mods. You can then share these mods through Steam Workshop.

Unofficial Tools for Modding

There are also unofficial tools that help with modding. Modding of Isaac, Basement Renovator, and many others offer extra features. They let you experiment with different ways to mod the game.

Log Readers and Debugging Tools

To fix problems in your mods, log readers like isaac-log can be very useful. They help you understand error logs and improve your mods. These tools help you create better, more stable content for the game.

Conversion Kits and Modding Resources

The-Binding-of-Isaac-Mod-Conversion-Kit helps bring PC mods to consoles. This way, more players can enjoy modded content. There are also websites and forums full of resources for modders. They offer guides, discussions, and mod showcases to inspire and help modders.

With these tools and resources, anyone can make their Binding of Isaac game better. Whether you’re new to modding or an expert, these can take your creative ideas to the next level.

Coins DonatedUnlockable Item
150 CoinsBlack Candle
10 CoinsBlue Map
666 CoinsStore Key
30 CoinsWooden Nickel
50 CoinsThere’s Options
400 CoinsRed Candle


The Binding of Isaac: Rebirth is a top-notch game. It offers a mix of challenges, humor, and deep themes. This makes it both fun and thought-provoking.

Have we covered everything in this guide? Yes, from the controls to the characters and the enemies. Don’t forget the DLCs too. We’ve given you all you need to know.

To truly get into the game, learn every aspect. Think about how to use items best. And remember, each character gives a unique experience.

As you play more, the story will start to reveal itself. There are also many different endings. Try to find them all. Plus, they all connect to the unique story of Isaac.


What is The Binding of Isaac: Rebirth?

The Binding of Isaac: Rebirth is a dungeon crawler known for its dark humor and religious nods. It creates levels randomly, and you can unlock special items in it. Players face challenging boss fights and have only one life in each run.

How do I play The Binding of Isaac: Rebirth?

Use WASD or a D-Pad/Left Analog Stick to move and the Arrow Keys to attack. You can also set off bombs and use other items. The story evolves as you defeat Mom and dive deeper.

What is the goal of The Binding of Isaac: Rebirth?

To win, gather items by beating bosses or exploring Treasure Rooms. Each victory lets you move further and face new foes. Your end goal is to overcome Mom.

Are there different characters to play as in The Binding of Isaac: Rebirth?

Absolutely, you’ll find diverse characters, each with unique strengths. You unlock more of them by playing. It adds a fresh dimension to the gameplay.

What are items in The Binding of Isaac: Rebirth?

Items change your abilities, enhancing your power or granting new skills. They play a key role in your success. Mixing and matching them wisely can make all the difference.

What can I expect in terms of enemies and boss battles in The Binding of Isaac: Rebirth?

The game throws a lot of enemies and tough bosses your way. Each one has a special attack style and strategy. Figuring out how to beat them is part of the fun.

Is there character progression in The Binding of Isaac: Rebirth?

Yes, you can unlock more items, characters, and challenges. This keeps things interesting and helps you grow as a player.

Are there any DLCs or additions to The Binding of Isaac: Rebirth?

Absolutely, the game has been expanded with DLC like Afterbirth, Afterbirth+, and Repentance. They bring in more content and fresh challenges.

Are there any tools or resources available to aid in playing The Binding of Isaac: Rebirth?

Yes, check out guide apps and websites for expert tips. They offer advice on everything from item combinations to strategy.

How can I maximize my experience with The Binding of Isaac: Rebirth?

To really get the most out of the game, learn from top guides and gain deep knowledge. This knowledge will help you enhance your gameplay and enjoy it even more.

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